Interactions médicamenteuses
Etrasimod + Mitoxantrone
Gravité: Majeure
Etrasimod and Mitoxantrone: major interaction.
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Résumé
Etrasimod lowers circulating lymphocytes, and mitoxantrone is immunosuppressive and myelosuppressive. Together they may increase the risk of serious infection, and the combination has not been studied.
Ce que signifie cette interaction, en termes simples
Etrasimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Mitoxantrone belongs to Central Nervous System.
Pourquoi elle survient
Additive immunosuppression from S1P receptor modulation plus cytotoxic marrow suppression.
Conduite à tenir
Avoid co-administration where possible, and allow washout of etrasimod after stopping. Monitor lymphocyte and neutrophil counts and for infection.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Mitoxantrone
- Adenovirus types 4 and 7 live + Mitoxantrone Contre-indiquée
- Axicabtagene ciloleucel + Mitoxantrone Majeure
- Belatacept + Mitoxantrone Majeure
- Brexucabtagene autoleucel + Mitoxantrone Majeure
- Ciltacabtagene autoleucel + Mitoxantrone Majeure
- Cyclosporine + Mitoxantrone Majeure
Autres interactions de Etrasimod
- Abatacept + Etrasimod Majeure
- Amiodarone + Etrasimod Majeure
- Anagrelide + Etrasimod Majeure
- Anakinra + Etrasimod Majeure
- Anti-thymocyte + Etrasimod Majeure
- Asenapine + Etrasimod Majeure
Questions fréquentes
Can I take Etrasimod with Mitoxantrone?
MediHelp rates the interaction as major. Etrasimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and mitoxantrone is immunosuppressive and myelosuppressive. Together they may increase the risk of serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration where possible, and allow washout of etrasimod after stopping. Monitor lymphocyte and neutrophil counts and for infection.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
