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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Fingolimod + Mitoxantrone

Gravité: Majeure

Fingolimod and Mitoxantrone: major interaction.

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Résumé

Mitoxantrone is myelosuppressive and immunosuppressive, and is also used in multiple sclerosis. With fingolimod, immunosuppression and infection risk may be increased, and prior mitoxantrone exposure has persistent effects.

Ce que signifie cette interaction, en termes simples

Fingolimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fingolimod belongs to Central Nervous System; Mitoxantrone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression from mitoxantrone marrow suppression and fingolimod lymphocyte sequestration.

Conduite à tenir

Avoid concurrent use; when switching from mitoxantrone, check blood counts and allow recovery before starting fingolimod. Monitor for infection.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fingolimod with Mitoxantrone?

MediHelp rates the interaction as major. Fingolimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitoxantrone is myelosuppressive and immunosuppressive, and is also used in multiple sclerosis. With fingolimod, immunosuppression and infection risk may be increased, and prior mitoxantrone exposure has persistent effects.

How serious is the interaction between Fingolimod and Mitoxantrone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; when switching from mitoxantrone, check blood counts and allow recovery before starting fingolimod. Monitor for infection.

What other medicines interact with Fingolimod?

MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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