Interactions médicamenteuses
Fluoxetine + Rasagiline
Gravité: Contre-indiquée
Fluoxetine and Rasagiline: contraindicated interaction.
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Résumé
Combining an SSRI with a monoamine oxidase B inhibitor can cause serotonin syndrome, with severe hyperthermia, rigidity and autonomic instability reported with antidepressants and rasagiline. Fluoxetine's very long-acting metabolite prolongs the risk after it is stopped.
Ce que signifie cette interaction, en termes simples
Fluoxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Pourquoi elle survient
Reduced serotonin breakdown from MAO inhibition combined with serotonin reuptake inhibition produces excess serotonergic activity.
Conduite à tenir
Do not co-administer; rasagiline labeling advises waiting about five weeks after stopping fluoxetine before starting rasagiline, and at least 14 days after stopping rasagiline before starting fluoxetine. Treat suspected serotonin syndrome by stopping both drugs and giving supportive care.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Fluoxetine
- Fluoxetine + Isocarboxazid Contre-indiquée
- Fluoxetine + Mavacamten Contre-indiquée
- Fluoxetine + Methylene blue Contre-indiquée
- Fluoxetine + Phenelzine Contre-indiquée
- Fluoxetine + Pimozide Contre-indiquée
- Fluoxetine + Selegiline Contre-indiquée
Autres interactions de Rasagiline
- Atomoxetine + Rasagiline Contre-indiquée
- Brimonidine + Rasagiline Contre-indiquée
- Bupropion-naltrexone + Rasagiline Contre-indiquée
- Bupropion + Rasagiline Contre-indiquée
- Clomipramine + Rasagiline Contre-indiquée
- Desvenlafaxine + Rasagiline Contre-indiquée
Questions fréquentes
Can I take Fluoxetine with Rasagiline?
MediHelp rates the interaction as contraindicated. Fluoxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an SSRI with a monoamine oxidase B inhibitor can cause serotonin syndrome, with severe hyperthermia, rigidity and autonomic instability reported with antidepressants and rasagiline. Fluoxetine's very long-acting metabolite prolongs the risk after it is stopped.
How serious is the interaction between Fluoxetine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; rasagiline labeling advises waiting about five weeks after stopping fluoxetine before starting rasagiline, and at least 14 days after stopping rasagiline before starting fluoxetine. Treat suspected serotonin syndrome by stopping both drugs and giving supportive care.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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