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Interactions médicamenteuses

Fluoxetine + Selegiline

Gravité: Contre-indiquée

Fluoxetine and Selegiline: contraindicated interaction.

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Résumé

Selegiline inhibits MAO-B and loses selectivity at higher doses, and fluoxetine inhibits serotonin reuptake. Serotonin syndrome has been reported, and fluoxetine also inhibits CYP2D6, raising selegiline exposure.

Ce que signifie cette interaction, en termes simples

Fluoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluoxetine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition plus serotonin reuptake inhibition; CYP inhibition raises selegiline levels

Conduite à tenir

Do not use together; allow at least 5 weeks after stopping fluoxetine before starting selegiline, and 14 days after stopping selegiline before starting fluoxetine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluoxetine with Selegiline?

MediHelp rates the interaction as contraindicated. Fluoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and loses selectivity at higher doses, and fluoxetine inhibits serotonin reuptake. Serotonin syndrome has been reported, and fluoxetine also inhibits CYP2D6, raising selegiline exposure.

How serious is the interaction between Fluoxetine and Selegiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 5 weeks after stopping fluoxetine before starting selegiline, and 14 days after stopping selegiline before starting fluoxetine.

What other medicines interact with Fluoxetine?

MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.

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