Interactions médicamenteuses
Flutamide + Telotristat etiprate
Gravité: Modérée
Flutamide and Telotristat etiprate: moderate interaction.
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Résumé
Flutamide is a CES2 substrate and telotristat may alter carboxylesterase handling of it, so flutamide exposure could change. The clinical consequence is uncertain, but flutamide carries a risk of liver toxicity.
Ce que signifie cette interaction, en termes simples
Flutamide and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Telotristat etiprate belongs to Gastrointestinal Tract.
Pourquoi elle survient
Possible modulation of CES2-mediated metabolism of flutamide; not well characterized clinically.
Conduite à tenir
Monitor liver function tests and clinical response to flutamide when telotristat is started or stopped.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Telotristat etiprate
Autres interactions de Flutamide
- Flutamide + Idelalisib Majeure
- Flutamide + Levoketoconazole Majeure
- Flutamide + Pexidartinib Majeure
- Flutamide + Pretomanid Majeure
- Flutamide + Valoctocogene roxaparvovec Majeure
- Apalutamide + Flutamide Modérée
Questions fréquentes
Can I take Flutamide with Telotristat etiprate?
MediHelp rates the interaction as moderate. Flutamide and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flutamide is a CES2 substrate and telotristat may alter carboxylesterase handling of it, so flutamide exposure could change. The clinical consequence is uncertain, but flutamide carries a risk of liver toxicity.
How serious is the interaction between Flutamide and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and clinical response to flutamide when telotristat is started or stopped.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
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