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Interactions médicamenteuses

Pentamidine + Ziprasidone

Gravité: Contre-indiquée

Pentamidine and Ziprasidone: contraindicated interaction.

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Résumé

Systemic pentamidine can prolong the QT interval and has been linked to torsades de pointes, and ziprasidone has similar effects. Using both increases the risk of serious ventricular arrhythmias. Pentamidine can also cause electrolyte disturbances that worsen this risk.

Ce que signifie cette interaction, en termes simples

Pentamidine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Pentamidine belongs to Anti Parasitic; Ziprasidone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation through cardiac repolarization delay, with pentamidine-related hypokalemia or hypomagnesemia as a contributor.

Conduite à tenir

Avoid concurrent use; hold ziprasidone or choose another anti-infective if possible. If unavoidable, correct electrolytes beforehand and monitor ECG continuously.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Pentamidine with Ziprasidone?

MediHelp rates the interaction as contraindicated. Pentamidine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Systemic pentamidine can prolong the QT interval and has been linked to torsades de pointes, and ziprasidone has similar effects. Using both increases the risk of serious ventricular arrhythmias. Pentamidine can also cause electrolyte disturbances that worsen this risk.

How serious is the interaction between Pentamidine and Ziprasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold ziprasidone or choose another anti-infective if possible. If unavoidable, correct electrolytes beforehand and monitor ECG continuously.

What other medicines interact with Ziprasidone?

MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.

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