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Interactions médicamenteuses

Mifepristone + Prednisone

Gravité: Contre-indiquée

Mifepristone and Prednisone: contraindicated interaction.

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Résumé

Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.

Ce que signifie cette interaction, en termes simples

Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Mifepristone belongs to Endocrine; Prednisone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Mifepristone antagonizes glucocorticoid receptors, opposing the effect of prednisone.

Conduite à tenir

Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Mifepristone with Prednisone?

MediHelp rates the interaction as contraindicated. Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.

How serious is the interaction between Mifepristone and Prednisone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.

What other medicines interact with Prednisone?

MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Radium-223 dichloride. The full list is on the Prednisone page.

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