Interazioni tra farmaci
Pentamidine + Thioridazine
Gravità: Controindicata
Pentamidine and Thioridazine: contraindicated interaction.
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Sintesi
Both drugs prolong the QT interval, and pentamidine has been linked to torsades de pointes. The combination markedly raises arrhythmia risk.
Cosa significa questa interazione in parole semplici
Pentamidine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pentamidine belongs to Anti Parasitic; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive QT prolongation through blockade of cardiac potassium channels.
Cosa fare
Avoid the combination and consider an alternative antipsychotic or anti-infective. If pentamidine is essential, stop thioridazine and monitor the ECG and electrolytes.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Altre interazioni di Pentamidine
- Clomipramine + Pentamidine Controindicata
- Desipramine + Pentamidine Controindicata
- Dronedarone + Pentamidine Controindicata
- Moxifloxacin + Pentamidine Controindicata
- Nortriptyline + Pentamidine Controindicata
- Pentamidine + Pimozide Controindicata
Domande frequenti
Can I take Pentamidine with Thioridazine?
MediHelp rates the interaction as contraindicated. Pentamidine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and pentamidine has been linked to torsades de pointes. The combination markedly raises arrhythmia risk.
How serious is the interaction between Pentamidine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative antipsychotic or anti-infective. If pentamidine is essential, stop thioridazine and monitor the ECG and electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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