Interazioni tra farmaci
Acalabrutinib + Pyrimethamine
Gravità: Moderata
Acalabrutinib and Pyrimethamine: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Pyrimethamine is a folate antagonist that can cause bone marrow suppression, and acalabrutinib can cause cytopenias such as neutropenia and thrombocytopenia. Combined use may increase the risk of myelosuppression.
Cosa significa questa interazione in parole semplici
Acalabrutinib and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Pyrimethamine belongs to Anti Parasitic.
Perché avviene
Additive myelosuppressive effects; pyrimethamine inhibits dihydrofolate reductase.
Cosa fare
Monitor complete blood counts regularly. Give folinic acid with pyrimethamine as indicated and reduce or interrupt doses if cytopenias develop.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Acalabrutinib e Pyrimethamine, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 7 giorni sul web. Nessuna carta.
Altre interazioni di Pyrimethamine
- Deferiprone + Pyrimethamine Maggiore
- Eliglustat + Pyrimethamine Maggiore
- Brexpiprazole + Pyrimethamine Moderata
- Dapsone + Pyrimethamine Moderata
- Folic acid + Pyrimethamine Moderata
- Fosphenytoin + Pyrimethamine Moderata
Altre interazioni di Acalabrutinib
- Abciximab + Acalabrutinib Maggiore
- Acalabrutinib + Amobarbital Maggiore
- Acalabrutinib + Apalutamide Maggiore
- Acalabrutinib + Apixaban Maggiore
- Acalabrutinib + Argatroban Maggiore
- Acalabrutinib + Carbamazepine Maggiore
Domande frequenti
Can I take Acalabrutinib with Pyrimethamine?
MediHelp rates the interaction as moderate. Acalabrutinib and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine is a folate antagonist that can cause bone marrow suppression, and acalabrutinib can cause cytopenias such as neutropenia and thrombocytopenia. Combined use may increase the risk of myelosuppression.
How serious is the interaction between Acalabrutinib and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Give folinic acid with pyrimethamine as indicated and reduce or interrupt doses if cytopenias develop.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Brexpiprazole. The full list is on the Pyrimethamine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
