Interazioni tra farmaci
Eliglustat + Pyrimethamine
Gravità: Maggiore
Eliglustat and Pyrimethamine: major interaction.
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Sintesi
Pyrimethamine is reported to inhibit CYP2D6, which could raise eliglustat exposure. Eliglustat can prolong PR, QTc and QRS intervals at high concentrations, so increased exposure raises arrhythmia risk.
Cosa significa questa interazione in parole semplici
Eliglustat and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
Perché avviene
Possible CYP2D6 inhibition by pyrimethamine reduces eliglustat clearance.
Cosa fare
Avoid if possible; otherwise reduce the eliglustat dose per labeling for CYP2D6 inhibitors and monitor the ECG. Do not combine with any CYP3A inhibitor.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Pyrimethamine
- Deferiprone + Pyrimethamine Maggiore
- Acalabrutinib + Pyrimethamine Moderata
- Brexpiprazole + Pyrimethamine Moderata
- Dapsone + Pyrimethamine Moderata
- Folic acid + Pyrimethamine Moderata
- Fosphenytoin + Pyrimethamine Moderata
Altre interazioni di Eliglustat
- Amiodarone + Eliglustat Controindicata
- Clarithromycin + Eliglustat Controindicata
- Dronedarone + Eliglustat Controindicata
- Eliglustat + Itraconazole Controindicata
- Eliglustat + Ketoconazole Controindicata
- Eliglustat + Pimozide Controindicata
Domande frequenti
Can I take Eliglustat with Pyrimethamine?
MediHelp rates the interaction as major. Eliglustat and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pyrimethamine is reported to inhibit CYP2D6, which could raise eliglustat exposure. Eliglustat can prolong PR, QTc and QRS intervals at high concentrations, so increased exposure raises arrhythmia risk.
How serious is the interaction between Eliglustat and Pyrimethamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the eliglustat dose per labeling for CYP2D6 inhibitors and monitor the ECG. Do not combine with any CYP3A inhibitor.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Acalabrutinib, Brexpiprazole. The full list is on the Pyrimethamine page.
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