Interazioni tra farmaci
Folic acid + Pyrimethamine
Gravità: Moderata
Folic acid and Pyrimethamine: moderate interaction.
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Sintesi
Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
Cosa significa questa interazione in parole semplici
Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
Perché avviene
Pharmacodynamic antagonism, as folic acid supplies the folate end-product whose synthesis pyrimethamine blocks.
Cosa fare
Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Pyrimethamine
- Deferiprone + Pyrimethamine Maggiore
- Eliglustat + Pyrimethamine Maggiore
- Acalabrutinib + Pyrimethamine Moderata
- Brexpiprazole + Pyrimethamine Moderata
- Dapsone + Pyrimethamine Moderata
- Fosphenytoin + Pyrimethamine Moderata
Altre interazioni di Folic acid
- Ethotoin + Folic acid Moderata
- Folic acid + Fosphenytoin Moderata
- Folic acid + Glucarpidase Moderata
- Folic acid + Methotrexate Moderata
- Folic acid + Pafolacianine Moderata
- Folic acid + Phenobarbital Moderata
Domande frequenti
Can I take Folic acid with Pyrimethamine?
MediHelp rates the interaction as moderate. Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
How serious is the interaction between Folic acid and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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