Interazioni tra farmaci
Dapsone + Pyrimethamine
Gravità: Moderata
Dapsone and Pyrimethamine: moderate interaction.
Ultimo aggiornamento
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Sintesi
Dapsone and pyrimethamine are used together for toxoplasmosis and malaria prophylaxis, but both can cause hematologic toxicity. Pyrimethamine is an antifolate that can cause bone marrow suppression, and dapsone can cause hemolysis and methemoglobinemia. The combination increases the risk of anemia, neutropenia and thrombocytopenia.
Cosa significa questa interazione in parole semplici
Dapsone and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Pyrimethamine belongs to Anti Parasitic.
Perché avviene
Additive hematologic toxicity: antifolate marrow suppression from pyrimethamine plus oxidative hemolysis from dapsone.
Cosa fare
Screen for G6PD deficiency and monitor complete blood counts regularly. Give folinic acid with pyrimethamine as recommended in treatment protocols.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Dapsone
- Bcg vaccine live + Dapsone Maggiore
- Dapsone + Primaquine Maggiore
- Apalutamide + Dapsone Moderata
- Belzutifan + Dapsone Moderata
- Bosentan + Dapsone Moderata
- Bupivacaine implant + Dapsone Moderata
Altre interazioni di Pyrimethamine
- Deferiprone + Pyrimethamine Maggiore
- Eliglustat + Pyrimethamine Maggiore
- Acalabrutinib + Pyrimethamine Moderata
- Brexpiprazole + Pyrimethamine Moderata
- Folic acid + Pyrimethamine Moderata
- Fosphenytoin + Pyrimethamine Moderata
Domande frequenti
Can I take Dapsone with Pyrimethamine?
MediHelp rates the interaction as moderate. Dapsone and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapsone and pyrimethamine are used together for toxoplasmosis and malaria prophylaxis, but both can cause hematologic toxicity. Pyrimethamine is an antifolate that can cause bone marrow suppression, and dapsone can cause hemolysis and methemoglobinemia. The combination increases the risk of anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Dapsone and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for G6PD deficiency and monitor complete blood counts regularly. Give folinic acid with pyrimethamine as recommended in treatment protocols.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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