Interazioni tra farmaci
Fosphenytoin + Pyrimethamine
Gravità: Moderata
Fosphenytoin and Pyrimethamine: moderate interaction.
Ultimo aggiornamento
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Sintesi
Pyrimethamine is an antifolate and phenytoin (the active form of fosphenytoin) can also lower folate status. Together they may add to folate deficiency and haematological toxicity. Reports of reduced anticonvulsant effect are inconsistent.
Cosa significa questa interazione in parole semplici
Fosphenytoin and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosphenytoin belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
Perché avviene
Additive folate antagonism; pyrimethamine inhibits dihydrofolate reductase and phenytoin impairs folate handling, and phenytoin levels may also change through unclear mechanisms.
Cosa fare
Monitor complete blood counts and seizure control, and check phenytoin concentrations if control changes. Give folinic acid with pyrimethamine as usually recommended.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Pyrimethamine
- Deferiprone + Pyrimethamine Maggiore
- Eliglustat + Pyrimethamine Maggiore
- Acalabrutinib + Pyrimethamine Moderata
- Brexpiprazole + Pyrimethamine Moderata
- Dapsone + Pyrimethamine Moderata
- Folic acid + Pyrimethamine Moderata
Altre interazioni di Fosphenytoin
- Dronedarone + Fosphenytoin Controindicata
- Fosphenytoin + Ledipasvir-sofosbuvir Controindicata
- Fosphenytoin + Lorlatinib Controindicata
- Fosphenytoin + Lurasidone Controindicata
- Fosphenytoin + Ranolazine Controindicata
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
Domande frequenti
Can I take Fosphenytoin with Pyrimethamine?
MediHelp rates the interaction as moderate. Fosphenytoin and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine is an antifolate and phenytoin (the active form of fosphenytoin) can also lower folate status. Together they may add to folate deficiency and haematological toxicity. Reports of reduced anticonvulsant effect are inconsistent.
How serious is the interaction between Fosphenytoin and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and seizure control, and check phenytoin concentrations if control changes. Give folinic acid with pyrimethamine as usually recommended.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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