Interazioni tra farmaci
Brexpiprazole + Pyrimethamine
Gravità: Moderata
Brexpiprazole and Pyrimethamine: moderate interaction.
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Sintesi
Pyrimethamine may raise brexpiprazole exposure by inhibiting its CYP2D6 metabolism. Higher levels could increase sedation, akathisia, orthostatic hypotension and other adverse effects, especially if a CYP3A4 inhibitor is also given.
Cosa significa questa interazione in parole semplici
Brexpiprazole and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
Perché avviene
Inhibition of CYP2D6-mediated metabolism of brexpiprazole.
Cosa fare
Monitor for adverse effects of brexpiprazole during co-use. Reduce the brexpiprazole dose to a quarter of usual if a strong or moderate CYP3A4 inhibitor is also given with a CYP2D6 inhibitor.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Pyrimethamine
- Deferiprone + Pyrimethamine Maggiore
- Eliglustat + Pyrimethamine Maggiore
- Acalabrutinib + Pyrimethamine Moderata
- Dapsone + Pyrimethamine Moderata
- Folic acid + Pyrimethamine Moderata
- Fosphenytoin + Pyrimethamine Moderata
Altre interazioni di Brexpiprazole
- Alfentanil + Brexpiprazole Maggiore
- Amisulpride + Brexpiprazole Maggiore
- Apalutamide + Brexpiprazole Maggiore
- Atazanavir + Brexpiprazole Maggiore
- Benzhydrocodone / acetaminophen + Brexpiprazole Maggiore
- Brexpiprazole + Buprenorphine buccal Maggiore
Domande frequenti
Can I take Brexpiprazole with Pyrimethamine?
MediHelp rates the interaction as moderate. Brexpiprazole and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine may raise brexpiprazole exposure by inhibiting its CYP2D6 metabolism. Higher levels could increase sedation, akathisia, orthostatic hypotension and other adverse effects, especially if a CYP3A4 inhibitor is also given.
How serious is the interaction between Brexpiprazole and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of brexpiprazole during co-use. Reduce the brexpiprazole dose to a quarter of usual if a strong or moderate CYP3A4 inhibitor is also given with a CYP2D6 inhibitor.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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