Interazioni tra farmaci
Azathioprine + Valoctocogene roxaparvovec
Gravità: Moderata
Azathioprine and Valoctocogene roxaparvovec: moderate interaction.
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Sintesi
Valoctocogene roxaparvovec commonly causes ALT elevations, and azathioprine can independently injure the liver. Concurrent use may increase the risk or severity of liver enzyme elevations and could confound their interpretation.
Cosa significa questa interazione in parole semplici
Azathioprine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Valoctocogene roxaparvovec belongs to Miscellaneous.
Perché avviene
Additive hepatotoxicity from the gene therapy's hepatic transduction and immune response and azathioprine's hepatotoxic potential.
Cosa fare
Monitor liver enzymes closely, as recommended after gene therapy, and consider alternatives to azathioprine where possible. Evaluate promptly for the need for corticosteroids if ALT rises.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Controindicata
- Azathioprine + Bcg vaccine live Controindicata
- Azathioprine + Febuxostat Controindicata
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Controindicata
- Azathioprine + Measles mumps and rubella vaccine Controindicata
- Azathioprine + Measles mumps and rubella vaccine live Controindicata
Altre interazioni di Valoctocogene roxaparvovec
Domande frequenti
Can I take Azathioprine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Azathioprine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes ALT elevations, and azathioprine can independently injure the liver. Concurrent use may increase the risk or severity of liver enzyme elevations and could confound their interpretation.
How serious is the interaction between Azathioprine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely, as recommended after gene therapy, and consider alternatives to azathioprine where possible. Evaluate promptly for the need for corticosteroids if ALT rises.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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