Interazioni tra farmaci
Cabozantinib + Posaconazole
Gravità: Maggiore
Cabozantinib and Posaconazole: major interaction.
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Sintesi
Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
Cosa significa questa interazione in parole semplici
Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Perché avviene
Strong CYP3A4 inhibition by posaconazole reduces the metabolic clearance of cabozantinib.
Cosa fare
Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Posaconazole
- Artemether + Posaconazole Controindicata
- Avanafil + Posaconazole Controindicata
- Cobimetinib + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine intranasal + Posaconazole Controindicata
- Dihydroergotamine + Posaconazole Controindicata
Altre interazioni di Cabozantinib
- Apalutamide + Cabozantinib Maggiore
- Cabozantinib + Carbamazepine Maggiore
- Cabozantinib + Clarithromycin Maggiore
- Cabozantinib + Efavirenz Maggiore
- Cabozantinib + Enzalutamide Maggiore
- Cabozantinib + Itraconazole Maggiore
Domande frequenti
Can I take Cabozantinib with Posaconazole?
MediHelp rates the interaction as major. Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
How serious is the interaction between Cabozantinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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