Interazioni tra farmaci
Calcium carbonate + Delafloxacin
Gravità: Moderata
Calcium carbonate and Delafloxacin: moderate interaction.
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Sintesi
Oral delafloxacin binds to calcium and other polyvalent cations in the gut, forming poorly absorbed chelates. Systemic exposure falls and may lead to subtherapeutic antibacterial levels and treatment failure.
Cosa significa questa interazione in parole semplici
Calcium carbonate and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Delafloxacin belongs to Anti Bacterial.
Perché avviene
Chelation of delafloxacin by calcium cations in the gastrointestinal tract reduces its oral absorption.
Cosa fare
Give oral delafloxacin at least 2 hours before or 6 hours after calcium carbonate. Alternatively use intravenous delafloxacin if separation is not feasible.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Calcium carbonate
Altre interazioni di Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderata
- Calcium + Delafloxacin Moderata
- Carbonyl iron + Delafloxacin Moderata
- Delafloxacin + Didanosine Moderata
- Delafloxacin + Ferrous fumarate Moderata
- Delafloxacin + Ferrous gluconate Moderata
Domande frequenti
Can I take Calcium carbonate with Delafloxacin?
MediHelp rates the interaction as moderate. Calcium carbonate and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral delafloxacin binds to calcium and other polyvalent cations in the gut, forming poorly absorbed chelates. Systemic exposure falls and may lead to subtherapeutic antibacterial levels and treatment failure.
How serious is the interaction between Calcium carbonate and Delafloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after calcium carbonate. Alternatively use intravenous delafloxacin if separation is not feasible.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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