Interazioni tra farmaci
Cefazolin + Plazomicin
Gravità: Moderata
Cefazolin and Plazomicin: moderate interaction.
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Sintesi
Cefazolin given with plazomicin may add to the risk of kidney injury, and plazomicin carries its own risk of nephrotoxicity, ototoxicity and neuromuscular blockade. Impaired renal function would increase plazomicin exposure and toxicity.
Cosa significa questa interazione in parole semplici
Cefazolin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Perché avviene
Additive nephrotoxic potential, with reduced aminoglycoside clearance if renal function declines.
Cosa fare
Monitor serum creatinine and plazomicin concentrations during combined use. Adjust the plazomicin dose to renal function and monitor for hearing or balance changes.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefazolin
- Amikacin + Cefazolin Moderata
- Bcg vaccine live + Cefazolin Moderata
- Cefazolin + Cholera vaccine Moderata
- Cefazolin + Dexamethasone-tobramycin Moderata
- Cefazolin + Gentamicin Moderata
- Cefazolin + Kanamycin Moderata
Altre interazioni di Plazomicin
- Cefaclor + Plazomicin Moderata
- Cefadroxil + Plazomicin Moderata
- Cefalexin + Plazomicin Moderata
- Cefditoren + Plazomicin Moderata
- Cefepime + Plazomicin Moderata
- Cefixime + Plazomicin Moderata
Domande frequenti
Can I take Cefazolin with Plazomicin?
MediHelp rates the interaction as moderate. Cefazolin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefazolin given with plazomicin may add to the risk of kidney injury, and plazomicin carries its own risk of nephrotoxicity, ototoxicity and neuromuscular blockade. Impaired renal function would increase plazomicin exposure and toxicity.
How serious is the interaction between Cefazolin and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations during combined use. Adjust the plazomicin dose to renal function and monitor for hearing or balance changes.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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