Interazioni tra farmaci
Dofetilide + Moxifloxacin
Gravità: Controindicata
Dofetilide and Moxifloxacin: contraindicated interaction.
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Sintesi
Dofetilide is a potent QT-prolonging antiarrhythmic with a high risk of torsades de pointes, and moxifloxacin adds further QT prolongation. The combination is dangerous and should not be used.
Cosa significa questa interazione in parole semplici
Dofetilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
Perché avviene
Additive pharmacodynamic QT prolongation.
Cosa fare
Avoid the combination and use a non-QT-prolonging antibiotic. Dofetilide patients need continuous ECG monitoring at initiation and electrolyte correction.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Moxifloxacin
- Amiodarone + Moxifloxacin Controindicata
- Arsenic trioxide + Moxifloxacin Controindicata
- Disopyramide + Moxifloxacin Controindicata
- Dronedarone + Moxifloxacin Controindicata
- Droperidol + Moxifloxacin Controindicata
- Ibutilide + Moxifloxacin Controindicata
Altre interazioni di Dofetilide
- Amiodarone + Dofetilide Controindicata
- Amisulpride + Dofetilide Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Controindicata
- Candesartan-hydrochlorothiazide + Dofetilide Controindicata
- Captopril-hydrochlorothiazide + Dofetilide Controindicata
Domande frequenti
Can I take Dofetilide with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Dofetilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide is a potent QT-prolonging antiarrhythmic with a high risk of torsades de pointes, and moxifloxacin adds further QT prolongation. The combination is dangerous and should not be used.
How serious is the interaction between Dofetilide and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. Dofetilide patients need continuous ECG monitoring at initiation and electrolyte correction.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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