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Interazioni tra farmaci

Dihydroergotamine + Naratriptan

Gravità: Controindicata

Dihydroergotamine and Naratriptan: contraindicated interaction.

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Sintesi

Naratriptan and dihydroergotamine each cause vasoconstriction, and together they may prolong vasospastic reactions. This can cause cardiac, cerebral or peripheral ischemia.

Cosa significa questa interazione in parole semplici

Dihydroergotamine and Naratriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.

Livello di evidenza: High

Perché avviene

Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects.

Cosa fare

Do not use together and keep at least 24 hours between them. Use one agent per attack.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Dihydroergotamine with Naratriptan?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Naratriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naratriptan and dihydroergotamine each cause vasoconstriction, and together they may prolong vasospastic reactions. This can cause cardiac, cerebral or peripheral ischemia.

How serious is the interaction between Dihydroergotamine and Naratriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together and keep at least 24 hours between them. Use one agent per attack.

What other medicines interact with Naratriptan?

MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Naratriptan page.

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