Interazioni tra farmaci
Dobutamine + Linezolid
Gravità: Maggiore
Dobutamine and Linezolid: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
Cosa significa questa interazione in parole semplici
Dobutamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Linezolid belongs to Anti Bacterial.
Perché avviene
Reduced catecholamine degradation (MAO inhibition) with sympathomimetic stimulation
Cosa fare
Avoid where possible; if dobutamine is required in a patient taking linezolid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Dobutamine e Linezolid, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Linezolid
- Amoxapine + Linezolid Controindicata
- Atomoxetine + Linezolid Controindicata
- Benzphetamine + Linezolid Controindicata
- Brimonidine + Linezolid Controindicata
- Bupropion-naltrexone + Linezolid Controindicata
- Bupropion + Linezolid Controindicata
Altre interazioni di Dobutamine
- Budesonide-formoterol + Dobutamine Maggiore
- Dihydroergotamine intranasal + Dobutamine Maggiore
- Dihydroergotamine + Dobutamine Maggiore
- Dobutamine + Ergotamine Maggiore
- Dobutamine + Ether Maggiore
- Dobutamine + Isocarboxazid Maggiore
Domande frequenti
Can I take Dobutamine with Linezolid?
MediHelp rates the interaction as major. Dobutamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
How serious is the interaction between Dobutamine and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if dobutamine is required in a patient taking linezolid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
