Interazioni tra farmaci
Dobutamine + Ergotamine
Gravità: Maggiore
Dobutamine and Ergotamine: major interaction.
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Sintesi
Ergotamine causes potent peripheral and coronary vasoconstriction, and dobutamine stimulates adrenergic receptors, adding vasoconstrictor and pressor effects. The combination can produce severe hypertension and peripheral or cardiac ischaemia.
Cosa significa questa interazione in parole semplici
Dobutamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Ergotamine belongs to Central Nervous System.
Perché avviene
Additive vasoconstriction (pharmacodynamic)
Cosa fare
Avoid the combination; if a vasoactive agent is needed in a patient exposed to ergotamine, use the lowest dose and monitor perfusion and blood pressure.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Dobutamine
- Budesonide-formoterol + Dobutamine Maggiore
- Dihydroergotamine intranasal + Dobutamine Maggiore
- Dihydroergotamine + Dobutamine Maggiore
- Dobutamine + Ether Maggiore
- Dobutamine + Isocarboxazid Maggiore
- Dobutamine + Linezolid Maggiore
Altre interazioni di Ergotamine
- Almotriptan + Ergotamine Controindicata
- Atazanavir + Ergotamine Controindicata
- Clarithromycin + Ergotamine Controindicata
- Cobicistat + Ergotamine Controindicata
- Darunavir + Ergotamine Controindicata
- Dihydroergotamine intranasal + Ergotamine Controindicata
Domande frequenti
Can I take Dobutamine with Ergotamine?
MediHelp rates the interaction as major. Dobutamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes potent peripheral and coronary vasoconstriction, and dobutamine stimulates adrenergic receptors, adding vasoconstrictor and pressor effects. The combination can produce severe hypertension and peripheral or cardiac ischaemia.
How serious is the interaction between Dobutamine and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a vasoactive agent is needed in a patient exposed to ergotamine, use the lowest dose and monitor perfusion and blood pressure.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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