Interazioni tra farmaci
Fluconazole + Mavacamten
Gravità: Controindicata
Fluconazole and Mavacamten: contraindicated interaction.
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Sintesi
Mavacamten is cleared mainly by CYP2C19, with a contribution from CYP3A4, and fluconazole inhibits both enzymes. Higher mavacamten exposure can excessively reduce ejection fraction and cause heart failure from systolic dysfunction. Labeling contraindicates moderate to strong CYP2C19 inhibitors.
Cosa significa questa interazione in parole semplici
Fluconazole and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Mavacamten belongs to Cardiovascular.
Perché avviene
Fluconazole inhibits CYP2C19 and CYP3A4, reducing mavacamten clearance.
Cosa fare
Do not combine them. If fluconazole is needed, interrupt mavacamten per labeling and monitor LVEF.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
Altre interazioni di Mavacamten
- Apalutamide + Mavacamten Controindicata
- Carbamazepine + Mavacamten Controindicata
- Clarithromycin + Mavacamten Controindicata
- Dexlansoprazole + Mavacamten Controindicata
- Efavirenz + Mavacamten Controindicata
- Enzalutamide + Mavacamten Controindicata
Domande frequenti
Can I take Fluconazole with Mavacamten?
MediHelp rates the interaction as contraindicated. Fluconazole and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared mainly by CYP2C19, with a contribution from CYP3A4, and fluconazole inhibits both enzymes. Higher mavacamten exposure can excessively reduce ejection fraction and cause heart failure from systolic dysfunction. Labeling contraindicates moderate to strong CYP2C19 inhibitors.
How serious is the interaction between Fluconazole and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them. If fluconazole is needed, interrupt mavacamten per labeling and monitor LVEF.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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