Interazioni tra farmaci
Glycerol phenylbutyrate + Hydrocortisone
Gravità: Moderata
Glycerol phenylbutyrate and Hydrocortisone: moderate interaction.
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Sintesi
Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.
Cosa significa questa interazione in parole semplici
Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Perché avviene
Corticosteroid-induced protein breakdown increases nitrogen load and ammonia production, counteracting nitrogen scavenging.
Cosa fare
Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Hydrocortisone
- Hydrocortisone + Mifepristone Controindicata
- Hydrocortisone + Poliovirus vaccine live oral trivalent Controindicata
- Hydrocortisone + Smallpox vaccine live Controindicata
- Adenovirus types 4 and 7 live + Hydrocortisone Maggiore
- Aldesleukin + Hydrocortisone Maggiore
- Aspirin + Hydrocortisone Maggiore
Altre interazioni di Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Maggiore
- Glycerol phenylbutyrate + Sodium valproate Maggiore
- Glycerol phenylbutyrate + Valproic acid Maggiore
- Cyclosporin + Glycerol phenylbutyrate Moderata
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderata
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderata
Domande frequenti
Can I take Glycerol phenylbutyrate with Hydrocortisone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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