Interazioni tra farmaci
Isosorbide dinitrate + Methylergonovine
Gravità: Maggiore
Isosorbide dinitrate and Methylergonovine: major interaction.
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Sintesi
Methylergonovine is a vasoconstrictor that can oppose the antianginal and vasodilator effects of nitrates. Ergot-induced coronary vasospasm may precipitate angina and may raise blood pressure.
Cosa significa questa interazione in parole semplici
Isosorbide dinitrate and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Pharmacodynamic antagonism: ergot vasoconstriction opposes nitrate vasodilation.
Cosa fare
Avoid where possible, especially in patients with coronary disease. If methylergonovine is essential, monitor blood pressure and chest pain closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide dinitrate + Sildenafil Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide dinitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide dinitrate Maggiore
Domande frequenti
Can I take Isosorbide dinitrate with Methylergonovine?
MediHelp rates the interaction as major. Isosorbide dinitrate and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylergonovine is a vasoconstrictor that can oppose the antianginal and vasodilator effects of nitrates. Ergot-induced coronary vasospasm may precipitate angina and may raise blood pressure.
How serious is the interaction between Isosorbide dinitrate and Methylergonovine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible, especially in patients with coronary disease. If methylergonovine is essential, monitor blood pressure and chest pain closely.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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