Interazioni tra farmaci
Isosorbide dinitrate + Riociguat
Gravità: Controindicata
Isosorbide dinitrate and Riociguat: contraindicated interaction.
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Sintesi
Both drugs increase cyclic GMP signalling in vascular smooth muscle, and together they can cause profound, sometimes refractory hypotension and syncope. Riociguat labeling contraindicates its use with nitrates in any form.
Cosa significa questa interazione in parole semplici
Isosorbide dinitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Perché avviene
Nitrates release nitric oxide while riociguat stimulates soluble guanylate cyclase, producing additive cGMP-mediated vasodilation.
Cosa fare
Do not co-administer riociguat with isosorbide dinitrate or other nitrates. Choose a non-nitrate antianginal if one is needed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Controindicata
- Isosorbide dinitrate + Sildenafil Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide dinitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide dinitrate Maggiore
- Isosorbide dinitrate + Methylergonovine Maggiore
Altre interazioni di Riociguat
- Avanafil + Riociguat Controindicata
- Dipyridamole + Riociguat Controindicata
- Isosorbide mononitrate + Riociguat Controindicata
- Nitroglycerin + Riociguat Controindicata
- Riociguat + Sildenafil Controindicata
- Riociguat + Tadalafil Controindicata
Domande frequenti
Can I take Isosorbide dinitrate with Riociguat?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs increase cyclic GMP signalling in vascular smooth muscle, and together they can cause profound, sometimes refractory hypotension and syncope. Riociguat labeling contraindicates its use with nitrates in any form.
How serious is the interaction between Isosorbide dinitrate and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer riociguat with isosorbide dinitrate or other nitrates. Choose a non-nitrate antianginal if one is needed.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Isosorbide dinitrate page.
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