Riferimento farmaci
Isosorbide dinitrate
Isosorbide dinitrate is a medicine in the class cardiovascular. It is used for angina pectoris.
- Classe del farmaco: Cardiovascular
- Indicato per: angina pectoris
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Cardiovascular
- Forme farmaceutiche comuni
- compressa, capsula, iniezione
- Dosaggi comuni
- 5 mg, 20 mg, 10 mg
- Interazioni note
- 47 (Controindicata: 5 · Maggiore: 2 · Moderata: 14 · Minore: 26)
- Nomi commerciali
- 31
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Vasodilating agent (nitric oxide donor); relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial oxygen demand; also improves coronary collateral circulation, lowering blood pressure, increasing heart rate, and causing occasional paradoxical bradycardia
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Angina Pectoris (Immediate release): 5-20 mg PO q8-12hr initially; maintenance: 10-40 mg PO q8-12hr
Gravidanza e allattamento
- Gravidanza
- Unknown Nitrate for angina and heart failure. No adequate human studies; embryotoxic in rabbits only at 35 to 150 times human doses. US label: use only if benefit justifies risk. Avoid maternal low blood pressure, which can reduce blood flow to the placenta.
- Allattamento
- Unknown Not known if it passes into milk; no published data and no LactMed record. US label: use caution while breastfeeding. Discuss regular use with a doctor; a better-studied option may be preferred.
Effetti indesiderati segnalati
- Headache
- Nausea
- Restlessness
- Dizziness
- Methemoglobinemia
Controindicazioni
- Hypersensitivity
- Recent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-life
- Severe anemia, shock, markedly low blood…
Chi deve prestare attenzione
- Concomitant administration with guanylate stimulator riociguat
- Severe hypotension, particularly with upright posture, may occur with even small doses; use caution in patients who may be volume depleted or who are already hypotensive
- Treat drug-induced headache with aspirin or acetaminophen
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (47)
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
- Isosorbide dinitrate + Methylergonovine Major
- Amlodipine-benazepril + Isosorbide dinitrate Moderate
- Arginine + Isosorbide dinitrate Moderate
- Benazepril + Isosorbide dinitrate Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Isosorbide dinitrate used for?
Isosorbide dinitrate is a medicine in the class cardiovascular. It is used for Angina pectoris.
What side effects have been reported with Isosorbide dinitrate?
Headache, Nausea, Restlessness, Dizziness, Methemoglobinemia.
Can Isosorbide dinitrate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Nitrate for angina and heart failure. No adequate human studies; embryotoxic in rabbits only at 35 to 150 times human doses. US label: use only if benefit justifies risk. Avoid maternal low blood pressure, which can reduce blood flow to the placenta. Breastfeeding: Unknown. Not known if it passes into milk; no published data and no LactMed record. US label: use caution while breastfeeding. Discuss regular use with a doctor; a better-studied option may be preferred.
What does Isosorbide dinitrate interact with?
MediHelp lists 47 known interactions for Isosorbide dinitrate. Contraindicated: 5 · Major: 2 · Moderate: 14 · Minor: 26. The most serious include Avanafil, Riociguat, Sildenafil.
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