Interazioni tra farmaci
Isosorbide dinitrate + Sildenafil
Gravità: Controindicata
Isosorbide dinitrate and Sildenafil: contraindicated interaction.
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Sintesi
Sildenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
Cosa significa questa interazione in parole semplici
Isosorbide dinitrate and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Perché avviene
PDE5 inhibition potentiates nitrate-induced cGMP vasodilation
Cosa fare
Contraindicated; do not give a nitrate within 24 hours of sildenafil, and use an alternative if both are required.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Sildenafil
- Amyl nitrite + Sildenafil Controindicata
- Atazanavir + Sildenafil Controindicata
- Cobicistat + Sildenafil Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Controindicata
- Glyceryl trinitrate pr + Sildenafil Controindicata
- Isosorbide mononitrate + Sildenafil Controindicata
Altre interazioni di Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide dinitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide dinitrate Maggiore
- Isosorbide dinitrate + Methylergonovine Maggiore
Domande frequenti
Can I take Isosorbide dinitrate with Sildenafil?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sildenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
How serious is the interaction between Isosorbide dinitrate and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 24 hours of sildenafil, and use an alternative if both are required.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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