Interazioni tra farmaci
Isosorbide dinitrate + Vardenafil
Gravità: Controindicata
Isosorbide dinitrate and Vardenafil: contraindicated interaction.
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Sintesi
Vardenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
Cosa significa questa interazione in parole semplici
Isosorbide dinitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Perché avviene
PDE5 inhibition potentiates nitrate-induced cGMP vasodilation
Cosa fare
Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Vardenafil
- Amyl nitrite + Vardenafil Controindicata
- Glyceryl trinitrate pr + Vardenafil Controindicata
- Isosorbide mononitrate + Vardenafil Controindicata
- Nicorandil + Vardenafil Controindicata
- Nitroglycerin po + Vardenafil Controindicata
- Nitroglycerin rectal + Vardenafil Controindicata
Altre interazioni di Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide dinitrate + Sildenafil Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Ergotamine + Isosorbide dinitrate Maggiore
- Isosorbide dinitrate + Methylergonovine Maggiore
Domande frequenti
Can I take Isosorbide dinitrate with Vardenafil?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
How serious is the interaction between Isosorbide dinitrate and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide mononitrate. The full list is on the Vardenafil page.
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