Interazioni tra farmaci
Itraconazole + Tisotumab vedotin
Gravità: Moderata
Itraconazole and Tisotumab vedotin: moderate interaction.
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Sintesi
Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
Cosa significa questa interazione in parole semplici
Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Perché avviene
Strong CYP3A4 inhibition reduces the metabolism of MMAE.
Cosa fare
Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderata
- Clarithromycin + Tisotumab vedotin Moderata
- Ketoconazole + Tisotumab vedotin Moderata
- Mifepristone + Tisotumab vedotin Moderata
- Posaconazole + Tisotumab vedotin Moderata
- Tisotumab vedotin + Voriconazole Moderata
Domande frequenti
Can I take Itraconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
How serious is the interaction between Itraconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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