Interazioni tra farmaci
Tisotumab vedotin + Voriconazole
Gravità: Moderata
Tisotumab vedotin and Voriconazole: moderate interaction.
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Sintesi
Voriconazole may increase exposure to unconjugated MMAE, the cytotoxic payload released from tisotumab vedotin. This could heighten toxicities such as neutropenia, neuropathy and ocular or hepatic effects.
Cosa significa questa interazione in parole semplici
Tisotumab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tisotumab vedotin belongs to Oncology; Voriconazole belongs to Anti Fungals.
Perché avviene
Voriconazole inhibits CYP3A4, which metabolizes MMAE.
Cosa fare
Monitor for adverse reactions such as neuropathy and neutropenia, and consider an alternative to a strong CYP3A4 inhibitor if feasible. Interrupt or reduce tisotumab vedotin if toxicity occurs.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Voriconazole
- Avanafil + Voriconazole Controindicata
- Butabarbital + Voriconazole Controindicata
- Carbamazepine + Voriconazole Controindicata
- Conivaptan + Voriconazole Controindicata
- Dihydroergotamine intranasal + Voriconazole Controindicata
- Dihydroergotamine + Voriconazole Controindicata
Altre interazioni di Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderata
- Clarithromycin + Tisotumab vedotin Moderata
- Itraconazole + Tisotumab vedotin Moderata
- Ketoconazole + Tisotumab vedotin Moderata
- Mifepristone + Tisotumab vedotin Moderata
- Posaconazole + Tisotumab vedotin Moderata
Domande frequenti
Can I take Tisotumab vedotin with Voriconazole?
MediHelp rates the interaction as moderate. Tisotumab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase exposure to unconjugated MMAE, the cytotoxic payload released from tisotumab vedotin. This could heighten toxicities such as neutropenia, neuropathy and ocular or hepatic effects.
How serious is the interaction between Tisotumab vedotin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neuropathy and neutropenia, and consider an alternative to a strong CYP3A4 inhibitor if feasible. Interrupt or reduce tisotumab vedotin if toxicity occurs.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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