Interazioni tra farmaci
Posaconazole + Tisotumab vedotin
Gravità: Moderata
Posaconazole and Tisotumab vedotin: moderate interaction.
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Sintesi
The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
Cosa significa questa interazione in parole semplici
Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Perché avviene
Strong CYP3A4 inhibition by posaconazole reduces the clearance of released MMAE.
Cosa fare
Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Posaconazole
- Artemether + Posaconazole Controindicata
- Avanafil + Posaconazole Controindicata
- Cobimetinib + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine intranasal + Posaconazole Controindicata
- Dihydroergotamine + Posaconazole Controindicata
Altre interazioni di Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderata
- Clarithromycin + Tisotumab vedotin Moderata
- Itraconazole + Tisotumab vedotin Moderata
- Ketoconazole + Tisotumab vedotin Moderata
- Mifepristone + Tisotumab vedotin Moderata
- Tisotumab vedotin + Voriconazole Moderata
Domande frequenti
Can I take Posaconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
How serious is the interaction between Posaconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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