相互作用
Avatrombopag + Mifepristone
重症度: 中等度
Avatrombopag and Mifepristone: moderate interaction.
最終更新日
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概要
Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
この相互作用をわかりやすく説明すると
Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Mifepristone belongs to Endocrine.
なぜ起こるのか
Inhibition of CYP3A4 (with CYP2C9 contribution) metabolism of avatrombopag by mifepristone.
対処法
Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvatrombopagとMifepristoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mifepristoneのその他の相互作用
Avatrombopagのその他の相互作用
よくある質問
Can I take Avatrombopag with Mifepristone?
MediHelp rates the interaction as moderate. Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
How serious is the interaction between Avatrombopag and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
