相互作用
Cefepime + Streptomycin
重症度: 中等度
Cefepime and Streptomycin: moderate interaction.
最終更新日
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概要
Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
この相互作用をわかりやすく説明すると
Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
なぜ起こるのか
Additive renal tubular stress; the aminoglycoside accumulates in proximal tubular and inner ear cells and any reduction in renal function raises its exposure.
対処法
Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefepimeとStreptomycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefepimeのその他の相互作用
Streptomycinのその他の相互作用
よくある質問
Can I take Cefepime with Streptomycin?
MediHelp rates the interaction as moderate. Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
How serious is the interaction between Cefepime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
