相互作用
Miconazole + Ribociclib
重症度: 重大
Miconazole and Ribociclib: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, and oral or buccal miconazole inhibits CYP3A4, which may raise ribociclib exposure. The combination can increase the risk of QT prolongation and torsades de pointes.
この相互作用をわかりやすく説明すると
Miconazole and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Miconazole belongs to Anti Fungals; Ribociclib belongs to Oncology.
なぜ起こるのか
Additive QT prolongation, plus CYP3A4 inhibition by miconazole increasing ribociclib levels.
対処法
Avoid systemic miconazole where possible, or use an alternative antifungal. If combined, monitor ECG and electrolytes and consider reducing ribociclib dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MiconazoleとRibociclibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ribociclibのその他の相互作用
Miconazoleのその他の相互作用
よくある質問
Can I take Miconazole with Ribociclib?
MediHelp rates the interaction as major. Miconazole and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and oral or buccal miconazole inhibits CYP3A4, which may raise ribociclib exposure. The combination can increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Miconazole and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic miconazole where possible, or use an alternative antifungal. If combined, monitor ECG and electrolytes and consider reducing ribociclib dose.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
