医薬品リファレンス
Isavuconazole
Isavuconazole is a medicine in the class anti fungals. It is used for aspergillosis.
- 薬効分類: Anti Fungals
- 効能・効果: aspergillosis
最終更新日 出典: EMA SmPC
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要点
- 薬効分類
- Anti Fungals
- ATCコード
- J02AC05
- 一般的な規格
- 100 mg
- 既知の相互作用
- 15 (併用禁忌: 8 · 重大: 1 · 中等度: 5 · 軽度: 1)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Fungicidal triazole that blocks ergosterol synthesis by inhibiting lanosterol 14-alpha-demethylase, causing methylated sterol precursors to accumulate and ergosterol to deplete, which weakens the fungal cell membrane.
成人の通常用量（添付文書の要約）
Invasive aspergillosis or mucormycosis (adults): loading dose 200 mg isavuconazole IV every 8 hours for the first 48 hours (six administrations); then maintenance 200 mg once daily, starting 12 to 24 hours after the last loading dose.
妊娠と授乳
- 妊娠
- Unsafe No human data; animal reproductive toxicity. Must not be used in pregnancy except in severe or life-threatening fungal infections where benefit outweighs risk. Not recommended in women of childbearing potential not using contraception.
- 授乳
- Unsafe Animal data show excretion in milk; risk to infants cannot be excluded. Breast-feeding should be discontinued during treatment.
報告されている副作用
- Elevated liver chemistry tests
- Nausea
- Vomiting
- Dyspnoea
- Abdominal pain
- Diarrhoea
禁忌
- Hypersensitivity to the active substance or excipients.
- Co-administration with ketoconazole.
- Co-administration with high-dose ritonavir (>200 mg every 12 hours).
注意が必要な方
- Hypersensitivity including anaphylaxis may occur; discontinue immediately if anaphylaxis occurs. Caution in patients hypersensitive to other azoles.
- Infusion-related reactions (hypotension, dyspnoea, dizziness, paraesthesia, nausea, headache) occur; stop the infusion if they occur.
- Severe cutaneous adverse reactions such as Stevens-Johnson syndrome have been reported with azoles; discontinue if they occur.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (15)
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
- Isavuconazole + Ritonavir Contraindicated
- Isavuconazole + Sirolimus Major
- Aprepitant + Isavuconazole Moderate
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Isavuconazoleの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Isavuconazole used for?
Isavuconazole is a medicine in the class anti fungals. It is used for Aspergillosis, Fungal infections.
What side effects have been reported with Isavuconazole?
Elevated liver chemistry tests, Nausea, Vomiting, Dyspnoea, Abdominal pain, Diarrhoea.
Can Isavuconazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data; animal reproductive toxicity. Must not be used in pregnancy except in severe or life-threatening fungal infections where benefit outweighs risk. Not recommended in women of childbearing potential not using contraception. Breastfeeding: Unsafe. Animal data show excretion in milk; risk to infants cannot be excluded. Breast-feeding should be discontinued during treatment.
What does Isavuconazole interact with?
MediHelp lists 15 known interactions for Isavuconazole. Contraindicated: 8 · Major: 1 · Moderate: 5 · Minor: 1. The most serious include Carbamazepine, Efavirenz, Etravirine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
