医薬品リファレンス
Clotrimazole
Clotrimazole is a medicine in the class anti fungals. It is used for candidiasis.
- 薬効分類: Anti Fungals
- 効能・効果: candidiasis
最終更新日 出典: US FDA label, UK SmPC
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Fungals
- 一般的な剤形
- クリーム剤, 溶液, 錠剤, 軟膏剤, スプレー剤, 散剤
- 一般的な規格
- 1 g/100 g, 10 mg/g, 1%
- 既知の相互作用
- 32 (重大: 4 · 中等度: 19 · 軽度: 9)
- 商品名
- 176
- 国・市場
- 5
何に使われるか
作用のしくみ
Antifungal activity Alters cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane, causing essential intracellular elements to leak
成人の通常用量（添付文書の要約）
Opharyngeal candidiasis (prophylaxis): 10 mg PO slowly dissolved in mouth tid or until steroids reduced to maintenance levels
妊娠と授乳
- 妊娠
- Safe Vaginal, skin and mouth forms give very little absorption, and studies show no rise in birth defects. A 7-day vaginal course is a preferred treatment for thrush in pregnancy; in late pregnancy insert pessaries by hand or with care.
- 授乳
- Safe Very little is absorbed from skin, vagina or mouth, so it is not expected in milk in meaningful amounts. Compatible with breastfeeding. If used on the nipple for thrush, wipe off before feeds.
報告されている副作用
- Edema
- Pruritus
- Erythema
- Blistering
禁忌
- Hypersensitivity to clotrimazole or to any of the excipients in the formulation.
注意が必要な方
- Condoms and diagrams may damage and fail to prevent pregnancy or sexually transmitted disease
- Not for use when having vaginal intercourse
- May cause mild increase in vaginal burning, itching or irritation
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (32)
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
- Clotrimazole + Cyclosporine Moderate
- Clotrimazole + Eliglustat Moderate
- Clotrimazole + Entrectinib Moderate
- Clotrimazole + Everolimus Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Clotrimazoleの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Clotrimazole used for?
Clotrimazole is a medicine in the class anti fungals. It is used for Candidiasis, Superficial dermatologic infection, Tinea, Vulvovaginal candidiasis.
What side effects have been reported with Clotrimazole?
Edema, Pruritus, Erythema, Blistering.
Can Clotrimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Vaginal, skin and mouth forms give very little absorption, and studies show no rise in birth defects. A 7-day vaginal course is a preferred treatment for thrush in pregnancy; in late pregnancy insert pessaries by hand or with care. Breastfeeding: Safe. Very little is absorbed from skin, vagina or mouth, so it is not expected in milk in meaningful amounts. Compatible with breastfeeding. If used on the nipple for thrush, wipe off before feeds.
What does Clotrimazole interact with?
MediHelp lists 32 known interactions for Clotrimazole. Major: 4 · Moderate: 19 · Minor: 9. The most serious include Lomitapide, Mavacamten, Mobocertinib.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
