相互作用
Dronedarone + Pentamidine
重症度: 併用禁忌
Dronedarone and Pentamidine: contraindicated interaction.
最終更新日
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概要
Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes. Combined with dronedarone the arrhythmia risk is substantially increased.
この相互作用をわかりやすく説明すると
Dronedarone and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Pentamidine belongs to Anti Parasitic.
なぜ起こるのか
Additive QT interval prolongation through cardiac repolarization effects.
対処法
Avoid the combination; use an alternative anti-infective or hold dronedarone, with ECG and electrolyte monitoring if unavoidable.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DronedaroneとPentamidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dronedaroneのその他の相互作用
Pentamidineのその他の相互作用
よくある質問
Can I take Dronedarone with Pentamidine?
MediHelp rates the interaction as contraindicated. Dronedarone and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes. Combined with dronedarone the arrhythmia risk is substantially increased.
How serious is the interaction between Dronedarone and Pentamidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative anti-infective or hold dronedarone, with ECG and electrolyte monitoring if unavoidable.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
