相互作用
Abatacept + Certolizumab pegol
重症度: 重大
Abatacept and Certolizumab pegol: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Combining a TNF inhibitor with abatacept increases serious infections without a consistent efficacy gain. Labeling for both classes discourages this combination.
この相互作用をわかりやすく説明すると
Abatacept and Certolizumab pegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abatacept belongs to Musculoskeletal; Certolizumab pegol belongs to Musculoskeletal.
なぜ起こるのか
Additive immunosuppression from TNF-alpha blockade and T-cell costimulation blockade.
対処法
Avoid concurrent use of these biologics and switch rather than combine. Monitor for infection during any transition period.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbataceptとCertolizumab pegolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Certolizumab pegolのその他の相互作用
- Adenovirus types 4 and 7 live + Certolizumab pegol 併用禁忌
- Bcg intravesical live + Certolizumab pegol 併用禁忌
- Bcg vaccine live + Certolizumab pegol 併用禁忌
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Certolizumab pegol + Measles mumps and rubella vaccine 併用禁忌
- Certolizumab pegol + Measles mumps and rubella vaccine live 併用禁忌
Abataceptのその他の相互作用
よくある質問
Can I take Abatacept with Certolizumab pegol?
MediHelp rates the interaction as major. Abatacept and Certolizumab pegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a TNF inhibitor with abatacept increases serious infections without a consistent efficacy gain. Labeling for both classes discourages this combination.
How serious is the interaction between Abatacept and Certolizumab pegol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of these biologics and switch rather than combine. Monitor for infection during any transition period.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
