相互作用
Aripiprazole + Oliceridine
重症度: 重大
Aripiprazole and Oliceridine: major interaction.
最終更新日 出典: UK SmPC
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概要
Oliceridine is an opioid that causes sedation and respiratory depression, and aripiprazole adds CNS depressant effects. Oliceridine is also partly metabolized by CYP3A4 and CYP2D6, which aripiprazole does not substantially affect, so the main concern is additive depression.
この相互作用をわかりやすく説明すると
Aripiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
なぜ起こるのか
Additive CNS and respiratory depression between an opioid and an antipsychotic.
対処法
Reserve combined use for patients without adequate alternatives, using the lowest oliceridine dose for the shortest duration. Monitor sedation and respiratory rate closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、AripiprazoleとOliceridineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: other CNS medicinal products with overlapping adverse reactions such as sedation; "caution should be used when aripiprazole is administered in combination with alcohol or other CNS medicinal products with overlapping adverse re… — electronic medicines compendium (UK SmPC)
Aripiprazoleのその他の相互作用
Oliceridineのその他の相互作用
よくある質問
Can I take Aripiprazole with Oliceridine?
MediHelp rates the interaction as major. Aripiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an opioid that causes sedation and respiratory depression, and aripiprazole adds CNS depressant effects. Oliceridine is also partly metabolized by CYP3A4 and CYP2D6, which aripiprazole does not substantially affect, so the main concern is additive depression.
How serious is the interaction between Aripiprazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives, using the lowest oliceridine dose for the shortest duration. Monitor sedation and respiratory rate closely.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
