相互作用
Amisulpride + Bedaquiline
重症度: 重大
Amisulpride and Bedaquiline: major interaction.
最終更新日
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概要
Bedaquiline prolongs the QT interval, and amisulpride has a similar dose-related effect. Together they increase the possibility of serious ventricular arrhythmia, particularly given the long half-life of bedaquiline.
この相互作用をわかりやすく説明すると
Amisulpride and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
なぜ起こるのか
Additive QT prolongation through effects on cardiac repolarization.
対処法
Avoid if an alternative is available. Otherwise obtain a baseline ECG, monitor QTc regularly, and keep potassium, magnesium and calcium within normal ranges.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとBedaquilineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amisulprideのその他の相互作用
Bedaquilineのその他の相互作用
よくある質問
Can I take Amisulpride with Bedaquiline?
MediHelp rates the interaction as major. Amisulpride and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval, and amisulpride has a similar dose-related effect. Together they increase the possibility of serious ventricular arrhythmia, particularly given the long half-life of bedaquiline.
How serious is the interaction between Amisulpride and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available. Otherwise obtain a baseline ECG, monitor QTc regularly, and keep potassium, magnesium and calcium within normal ranges.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
