相互作用
Apalutamide + Ethinyl estradiol-norgestimate
重症度: 重大
Apalutamide and Ethinyl estradiol-norgestimate: major interaction.
最終更新日
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概要
Apalutamide is a strong CYP3A4 inducer and can markedly lower exposure to ethinyl estradiol and norgestimate-derived progestins. This increases the risk of contraceptive failure.
この相互作用をわかりやすく説明すると
Apalutamide and Ethinyl estradiol-norgestimate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Ethinyl estradiol-norgestimate belongs to Endocrine.
なぜ起こるのか
Strong induction of CYP3A4 (and other enzymes) accelerates hormone metabolism.
対処法
Use non-hormonal contraception rather than relying on the combined pill. Maintain it during therapy and for a period after stopping per labeling.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとEthinyl estradiol-norgestimateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ethinyl estradiol-norgestimateのその他の相互作用
- Ethinyl estradiol-norgestimate + Fezolinetant 併用禁忌
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir 併用禁忌
- Ethinyl estradiol-norgestimate + Tranexamic acid 併用禁忌
- Aminocaproic acid + Ethinyl estradiol-norgestimate 重大
- Amobarbital + Ethinyl estradiol-norgestimate 重大
- Anastrozole + Ethinyl estradiol-norgestimate 重大
Apalutamideのその他の相互作用
よくある質問
Can I take Apalutamide with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as major. Apalutamide and Ethinyl estradiol-norgestimate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and can markedly lower exposure to ethinyl estradiol and norgestimate-derived progestins. This increases the risk of contraceptive failure.
How serious is the interaction between Apalutamide and Ethinyl estradiol-norgestimate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use non-hormonal contraception rather than relying on the combined pill. Maintain it during therapy and for a period after stopping per labeling.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
