相互作用
Aprepitant + Isavuconazole
重症度: 中等度
Aprepitant and Isavuconazole: moderate interaction.
最終更新日
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概要
Aprepitant is a weak CYP3A4 inducer and may modestly lower isavuconazole levels. Reduced antifungal exposure could affect treatment of invasive fungal infection.
この相互作用をわかりやすく説明すると
Aprepitant and Isavuconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Isavuconazole belongs to Anti Fungals.
なぜ起こるのか
Weak induction of CYP3A4 by aprepitant increases isavuconazole clearance.
対処法
Monitor clinical response and consider isavuconazole levels if available.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AprepitantとIsavuconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isavuconazoleのその他の相互作用
Aprepitantのその他の相互作用
よくある質問
Can I take Aprepitant with Isavuconazole?
MediHelp rates the interaction as moderate. Aprepitant and Isavuconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a weak CYP3A4 inducer and may modestly lower isavuconazole levels. Reduced antifungal exposure could affect treatment of invasive fungal infection.
How serious is the interaction between Aprepitant and Isavuconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider isavuconazole levels if available.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
