相互作用
Isavuconazole + Ketoconazole
重症度: 併用禁忌
Isavuconazole and Ketoconazole: contraindicated interaction.
最終更新日
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概要
Ketoconazole strongly inhibits CYP3A4 and markedly increases isavuconazole exposure. This raises the risk of isavuconazole toxicity such as hepatic effects and QT shortening.
この相互作用をわかりやすく説明すると
Isavuconazole and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazole belongs to Anti Fungals; Ketoconazole belongs to Anti Fungals.
なぜ起こるのか
Ketoconazole inhibits CYP3A4/5, reducing isavuconazole clearance.
対処法
Avoid co-administration; use a single azole. If unavoidable, monitor liver function and isavuconazole-related adverse effects.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、IsavuconazoleとKetoconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isavuconazoleのその他の相互作用
Ketoconazoleのその他の相互作用
よくある質問
Can I take Isavuconazole with Ketoconazole?
MediHelp rates the interaction as contraindicated. Isavuconazole and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole strongly inhibits CYP3A4 and markedly increases isavuconazole exposure. This raises the risk of isavuconazole toxicity such as hepatic effects and QT shortening.
How serious is the interaction between Isavuconazole and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration; use a single azole. If unavoidable, monitor liver function and isavuconazole-related adverse effects.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
