Drug interactions
Aprepitant + Isavuconazole
Severity: Moderate
Aprepitant and Isavuconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a weak CYP3A4 inducer and may modestly lower isavuconazole levels. Reduced antifungal exposure could affect treatment of invasive fungal infection.
What this interaction means in plain words
Aprepitant and Isavuconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Isavuconazole belongs to Anti Fungals.
Why it happens
Weak induction of CYP3A4 by aprepitant increases isavuconazole clearance.
What to do
Monitor clinical response and consider isavuconazole levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Isavuconazole?
MediHelp rates the interaction as moderate. Aprepitant and Isavuconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a weak CYP3A4 inducer and may modestly lower isavuconazole levels. Reduced antifungal exposure could affect treatment of invasive fungal infection.
How serious is the interaction between Aprepitant and Isavuconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider isavuconazole levels if available.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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