相互作用
Efavirenz + Isavuconazole
重症度: 併用禁忌
Efavirenz and Isavuconazole: contraindicated interaction.
最終更新日
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概要
Efavirenz is a moderate CYP3A4 inducer and may lower isavuconazole exposure, compromising antifungal efficacy. Isavuconazole could also alter efavirenz concentrations.
この相互作用をわかりやすく説明すると
Efavirenz and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Isavuconazole belongs to Anti Fungals.
なぜ起こるのか
Efavirenz induces CYP3A4/5, accelerating isavuconazole metabolism.
対処法
Avoid coadministration and use an alternative antiretroviral such as an integrase inhibitor-based regimen if feasible. If combined, monitor isavuconazole levels and clinical response.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、EfavirenzとIsavuconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isavuconazoleのその他の相互作用
Efavirenzのその他の相互作用
よくある質問
Can I take Efavirenz with Isavuconazole?
MediHelp rates the interaction as contraindicated. Efavirenz and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz is a moderate CYP3A4 inducer and may lower isavuconazole exposure, compromising antifungal efficacy. Isavuconazole could also alter efavirenz concentrations.
How serious is the interaction between Efavirenz and Isavuconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative antiretroviral such as an integrase inhibitor-based regimen if feasible. If combined, monitor isavuconazole levels and clinical response.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Etravirine, Ketoconazole. The full list is on the Isavuconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
