相互作用
Arsenic trioxide + Hydroxychloroquine
重症度: 併用禁忌
Arsenic trioxide and Hydroxychloroquine: contraindicated interaction.
最終更新日
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概要
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and adding hydroxychloroquine further increases this risk. The combination can lead to life-threatening arrhythmias.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Hydroxychloroquine belongs to Musculoskeletal.
なぜ起こるのか
Additive QT prolongation through effects on cardiac ion channels and repolarization.
対処法
Avoid concurrent use and choose an alternative to hydroxychloroquine during arsenic trioxide therapy. If it cannot be avoided, require continuous ECG surveillance with strict correction of potassium and magnesium.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとHydroxychloroquineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydroxychloroquineのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Hydroxychloroquine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and adding hydroxychloroquine further increases this risk. The combination can lead to life-threatening arrhythmias.
How serious is the interaction between Arsenic trioxide and Hydroxychloroquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative to hydroxychloroquine during arsenic trioxide therapy. If it cannot be avoided, require continuous ECG surveillance with strict correction of potassium and magnesium.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Cisapride, Dronedarone, Pimozide. The full list is on the Hydroxychloroquine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
