相互作用
Arsenic trioxide + Ziprasidone
重症度: 併用禁忌
Arsenic trioxide and Ziprasidone: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and arsenic trioxide is known to cause torsades de pointes and complete AV block. Together they markedly raise the risk of life-threatening ventricular arrhythmia. Ziprasidone labeling lists this combination as contraindicated.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Ziprasidone belongs to Central Nervous System.
なぜ起こるのか
Additive prolongation of cardiac repolarization through delayed rectifier potassium channel (hERG) blockade.
対処法
Do not co-administer; use an antipsychotic with lower QT liability if one is needed during arsenic trioxide therapy. Correct potassium and magnesium and monitor ECGs if any antipsychotic is unavoidable.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとZiprasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ziprasidoneのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Ziprasidone?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and arsenic trioxide is known to cause torsades de pointes and complete AV block. Together they markedly raise the risk of life-threatening ventricular arrhythmia. Ziprasidone labeling lists this combination as contraindicated.
How serious is the interaction between Arsenic trioxide and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an antipsychotic with lower QT liability if one is needed during arsenic trioxide therapy. Correct potassium and magnesium and monitor ECGs if any antipsychotic is unavoidable.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Bedaquiline. The full list is on the Ziprasidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
