相互作用
Atazanavir + Eltrombopag
重症度: 中等度
Atazanavir and Eltrombopag: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Atazanavir inhibits UGT1A1, and eltrombopag is partly cleared by UGT1A1 and UGT1A3. Eltrombopag exposure may rise, and both drugs can raise bilirubin and liver enzymes.
この相互作用をわかりやすく説明すると
Atazanavir and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Eltrombopag belongs to Miscellaneous.
なぜ起こるのか
Atazanavir inhibits UGT1A1 and possibly CYP-mediated clearance, which may reduce eltrombopag elimination.
対処法
Monitor liver function tests and bilirubin and review platelet response. Adjust the eltrombopag dose if hepatic abnormalities or excessive platelet counts occur.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとEltrombopagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Eltrombopagのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Eltrombopag?
MediHelp rates the interaction as moderate. Atazanavir and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits UGT1A1, and eltrombopag is partly cleared by UGT1A1 and UGT1A3. Eltrombopag exposure may rise, and both drugs can raise bilirubin and liver enzymes.
How serious is the interaction between Atazanavir and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and bilirubin and review platelet response. Adjust the eltrombopag dose if hepatic abnormalities or excessive platelet counts occur.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
