相互作用
Berotralstat + Eltrombopag
重症度: 中等度
Berotralstat and Eltrombopag: moderate interaction.
最終更新日
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概要
Berotralstat is a BCRP substrate, and eltrombopag inhibits BCRP. Berotralstat exposure may increase, with more gastrointestinal and QT-related adverse effects.
この相互作用をわかりやすく説明すると
Berotralstat and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Eltrombopag belongs to Miscellaneous.
なぜ起こるのか
Eltrombopag inhibits BCRP efflux transport, which may raise berotralstat absorption and exposure.
対処法
Monitor for berotralstat adverse effects such as gastrointestinal upset, and consider an ECG if risk factors for QT prolongation are present. Reduce the berotralstat dose if it is poorly tolerated.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BerotralstatとEltrombopagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Eltrombopagのその他の相互作用
Berotralstatのその他の相互作用
よくある質問
Can I take Berotralstat with Eltrombopag?
MediHelp rates the interaction as moderate. Berotralstat and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat is a BCRP substrate, and eltrombopag inhibits BCRP. Berotralstat exposure may increase, with more gastrointestinal and QT-related adverse effects.
How serious is the interaction between Berotralstat and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects such as gastrointestinal upset, and consider an ECG if risk factors for QT prolongation are present. Reduce the berotralstat dose if it is poorly tolerated.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
